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Human umbilical cord-derived mesenchymal stem cell (HUCMSC)-exosomes (EXOs) deliver miR-375 to CD4 + T cells and inhibit HDAC4 expression to increase the beclin-1 and LC3-II/LC3-I expression, promoting autophagy and inhibiting T-cell apoptosis and mitigating pathological changes, including the edema of RTECs, necrosis of renal tubules, and severe congestion induced by SAKI (Liu and Chen, 2024c)

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[PubMed: 7295199] 575

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While some studies showed mild heart rate increases, these were similar to those seen with other GLP-1RAs

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